Selected Publications

PubMed:     Dr. Paschke     Dr. Eszlinger

Peer-reviewed publications

Eszlinger M, Khalil M, Gillmor AH, Huang H, Stewardson P, McIntyre JB, Morrissy S, Paschke R. 2021 Histology-based molecular profiling improves mutation detection for advanced thyroid cancer. Genes Chromosomes Cancer 60(8):531-545

Stephenson A, Eszlinger M, Stewardson P, McIntyre JB, Boesenberg E, Bircan R, Sancak S, Gozu HI, Ghaznavi S, Krohn K, Paschke R. 2020 Sensitive Sequencing Analysis Suggests Thyrotropin Receptor and Guanine Nucleotide-Binding Protein G Subunit Alpha as Sole Driver Mutations in Hot Thyroid Nodules. Thyroid 30(10):1482-1489

Symonds CJ, Seal P, Ghaznavi S, Cheung WY, Paschke R. 2018 Thyroid nodule ultrasound reports in routine clinical practice provide insufficient information to estimate risk of malignancy. Endocrine 61(2):303-307

Eszlinger M, Lau L, Ghaznavi S, Symonds C, Chandarana SP, Khalil M, Paschke R 2017 Molecular profiling of thyroid nodule fine needle aspiration (FNA) cytology. Nat Rev Endocrinol 13(7):415-424

Eszlinger M, Böhme K, Ullmann M, Görke F, Siebolts U, Neumann A, Franzius C, Adam S, Molwitz T, Landvogt C, Amro B, Hach A, Feldmann B, Graf D, Wefer A, Niemann R, Bullmann C, Klaushenke G, Santen R, Tönshoff G, Ivancevic V, Kögler A, Bell E, Lorenz B, Kluge G, Hartenstein C, Ruschenburg I, Paschke R 2017 Evaluation of a two-year routine application of molecular testing of thyroid fine needle aspirations (FNA) using a 7-gene-panel in a primary refferral setting in Germany. Thyroid 27(3):402-411

Calebiro D, Grassi ES, Eszlinger M, Ronchi CL, Godbole A, Bathon K, Guizzardi F, de Filippis T, Krohn K, Jaeschke H, Schwarzmayr T, Bircan R, Gozu HI, Sancak S, Niedziela M, Strom TM, Fassnacht M, Persani L, Paschke R 2016 Recurrent EZH1 mutations in autonomous thyroid adenomas J Clin Invest.126(9):3383-8. doi: 10.1172/JCI84894

Stokowy T, Wojtas B, Jarzab B, Krohn K, Fredman D, Dralle H, Musholt T, Hauptmann S, Lange D, Hegedüs L, Paschke R, and Eszlinger M 2016 Two-miRNA-classifiers differentiate mutation-negative follicular thyroid carcinomas and follicular thyroid adenomas in Fine Needle Aspirations with high specificity Endocrine 54(2):440-447

Krane JF, Cibas ES, Alexander EK, Paschke R, Eszlinger M 2015 Molecular Analysis of Residual ThinPrep Material from Thyroid FNAs Increases Diagnostic Sensitivity Cancer Cytopathology 123(6):356-61

Eszlinger M, Piana S, Moll A, Bosenberg E, Bisagni A, Ciarrocchi A, Ragazzi M, Paschke R 2015 Molecular testing of thyroid fine needle aspirations (FNA) improves pre-surgical diagnosis and supports the histological identification of minimally invasive follicular thyroid carcinomas. Thyroid 25(4):401-409

Jaeschke H, Schaarschmidt J, Eszlinger M, Huth S, Puttinger R, Rittinger O, Meiler J, Paschke R 2014 A newly discovered TSHR variant (L665F) associated with non-autoimmune hyperthyroidism in an Austrian family induces constitutive TSHR activation by steric repulsion between TM1 and TM7. J Clin Endocrinol Metab:jc20141436

Wojtas B, Ferraz C, Stokowy T, Hauptmann S, Lange D, Dralle H, Musholt T, Jarzab B, Paschke R, Eszlinger M 2014 Differential miRNA expression defines migration and reduced apoptosis in follicular thyroid carcinomas. Mol Cell Endocrinol 388(1-2):1-9

Eszlinger M, Krogdahl A, Münz S, Rehfeld C, Precht Jensen EM, Ferraz C, Bösenberg E, Drieschner N, Scholz M, Hegedüs L, Paschke R. 2013 Impact of molecular screening for point mutations and rearrangements in routine air-dried Fine Needle Aspiration samples of thyroid nodules. Thyroid 24(2):305-13.

Ferraz C, Lorenz S, Wojtas B, Bornstein SR, Paschke R, Eszlinger M. 2013 Inverse Correlation of miRNA and Cell Cycle-Associated Genes Suggests Influence of miRNA on Benign Thyroid Nodule Tumorigenesis. J Clin Endocrinol Metab 98(1) E8-E16.

Ferraz C, Rehfeld C, Krogdahl A, Jensen EMP, Bosenberg E, Narz F, Hegedus L, Paschke R., Eszlinger M. 2012 Detection of PAX8/PPARG and RET/PTC Rearrangements Is Feasible in Routine Air-Dried Fine Needle Aspiration Smears. Thyroid 22 1025-1030.

Ferraz C, Eszlinger M, Paschke R. 2011 Current State and Future Perspective of Molecular Diagnosis of Fine-Needle Aspiration Biopsy of Thyroid Nodules. Journal of Clinical Endocrinology & Metabolism 96 2016-2026.

Eszlinger M, Krohn K, Kukulska A, Jarzab B, Paschke R. 2007 Perspectives and limitations of microarray-based gene expression profiling of thyroid tumors. Endocrine Reviews 28 322-338.

Eszlinger M, Krohn K, Berger K, Lauter J, Kropf S, Beck M, Fuhrer D, Paschke R. 2005 Gene expression analysis reveals evidence for increased expression of cell cycle-associated genes and G(q)-protein-protein kinase C signaling in cold thyroid nodules. Journal of Clinical Endocrinology & Metabolism 90 1163-1170.

Eszlinger M, Krohn K, Frenzel R, Kropf S, Tonjes A, Paschke R. 2004 Gene expression analysis reveals evidence for inactivation of the TGF-beta signaling cascade in autonomously functioning thyroid nodules. Oncogene 23 795-804.

Conference Abstracts

Lau L, Frolkis A, Stephenson A, Robertson L, Rabi D, Paschke R. (October 2019). Malignancy risk of hyperfunctioning thyroid nodules compared with non toxic nodules: Systematic review and a meta analysis. 89th Annual Meeting of the American Thyroid Association, Chicago, United States.

Lithgow K, Huang H, Chan D, Khalil M, Bristow M, Dinculescu V, Eszlinger M, Parkins V, Grundy P, Paschke R. (October 2019). Predicting response to resensitizationof radioiodine resistant thyroid cancer with whole exome sequencing. 22nd Annual Diabetes Canada/ Canadian Society of Endocrinology and Metabolism Professional Conference, Winnipeg, Canada.

Huang H, Khalil M, Paschke R, Eszlinger M. (October 2019). Molecular Variants Identified in Histologically Heterogeneous Radioiodine Resistant (RAIR) Metastatic Thyroid Cancers as Potential Actionable Targets. 89th Annual Meeting of the American Thyroid Association, Chicago, United States, Chicago, United States.

Stewardson P, Eszlinger M, Khalil M, Ghaznavi S, Punjwani Z, Symonds C, Demetrick D, Paschke R. (October 2019). Prospective Evaluation of the ThyroSPECTM Mutation Panel for the Diagnosis of Indeterminate Thyroid Fine Needle Aspiration Cytologies (FNAC) in the Southern Alberta Health Care Region. 89th Annual Meeting of the American Thyroid Association, Chicago, United States.

Ghaznavi SA, Clayton H, Eszlinger M, Khalil M, Symonds CJ, Paschke R. (October 2018). Thyroid nodule malignancy rates within a health care region with centralized pathology. 88th annual meeting of the American Thyroid Association, Washington D.C., United States.